Short answer

We found no documented interaction between Berberine and Herbal sleep blend in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Berberine

What it is: A compound from plants such as barberry and goldenseal, used in Chinese and Ayurvedic medicine.

What the research says: It may lower cholesterol, triglycerides and blood sugar, but the effect may be small and lifestyle changes are still needed.

Cautions

• Mild side effects can include appetite loss, upset stomach, diarrhea, constipation and rash.
• Not for pregnancy or breastfeeding: it may harm newborns.

Medicines to check

• Immune-suppressing drugs such as tacrolimus or cyclosporin: berberine may raise their levels
• Some diabetes drugs (sulfonylureas)
• Many prescription drugs processed by the liver: berberine may make them less effective
• Bosutinib (a cancer drug)

In Holitro: Berberine 500mg (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Berberine (updated June 2023)

Herbal sleep blend

What it is: A blend of calming herbs: valerian, hops, passionflower, skullcap and poppy.

What the research says: Evidence for valerian is inconsistent, and sleep doctors advise against it for chronic insomnia. Small studies suggest passionflower may add sleep time, and hops with valerian may help mild insomnia.

Cautions

• Valerian is generally safe short term; it can cause headache, stomach upset or vivid dreams, and withdrawal if stopped suddenly after long use.
• Passionflower can cause drowsiness or dizziness and shouldn't be used in pregnancy.
• Don't combine with alcohol.

Medicines to check

• Sedatives and sleep medicines: don't combine
• Anesthesia: stop at least 2 weeks before surgery (passionflower)
• Hormone-sensitive cancer: check with your doctor (hops)

In Holitro: Herbal Sleep Blend (450 mg per capsule)

Sources: NIH National Center for Complementary and Integrative Health: Valerian: Usefulness and Safety (updated May 2025); NIH National Center for Complementary and Integrative Health: Passionflower: Usefulness and Safety (updated April 2025); Memorial Sloan Kettering Cancer Center, About Herbs: Hops (updated February 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.