Can I take Melatonin SR with Theanine?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Melatonin SR
+
Theanine

Short answer

We found no documented interaction between Melatonin and L-theanine in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Melatonin (slow release)

What it is: A slow-release form of melatonin, the hormone the brain makes in the dark to set your sleep-wake clock.

What the research says: Melatonin may help with jet lag and some circadian sleep problems. Sleep-medicine guidelines say there isn't enough evidence to recommend it for chronic insomnia.

Cautions

  • Short-term use seems safe for most people; long-term safety isn't known.
  • Older adults may feel drowsy the next day.

Medicines to check

  • Blood thinners and epilepsy: use only under medical supervision

Source: NIH National Center for Complementary and Integrative Health: Melatonin: What You Need To Know (updated May 2024)

L-theanine

What it is: An amino acid found in green tea, taken for calm and sleep.

What the research says: Small studies suggest it may improve sleep; results for anxiety are mixed.

Cautions

  • No side effects have been reported for the supplement.
  • It may not be safe in pregnancy or while breastfeeding.

Medicines to check

  • Sleep medicines and sedatives (such as lorazepam, diazepam or zolpidem): may add to drowsiness

In Holitro: Theanine 200mg (200 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: L-Theanine (updated July 2026)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

Already Combined For You

Melatonin SR and Theanine don’t need separate bottles — both are already dosed together, every day, in our Sleep Pack.

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