Short answer

We found no documented interaction between Alpha-lipoic acid and Herbal sleep blend in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Alpha-lipoic acid

What it is: An antioxidant the body makes and uses to produce energy.

What the research says: It's used for diabetic nerve pain, and studies suggest it can improve insulin sensitivity.

Cautions

• It can cause nausea, vomiting and low blood sugar.
• Rare cases of a condition causing sudden low blood sugar have been reported.

Medicines to check

• Diabetes medicines: it can lower blood sugar further

In Holitro: Alpha Lipoic Acid (500 mg per capsule)

Source: Memorial Sloan Kettering Cancer Center, About Herbs: Alpha-Lipoic Acid (updated July 2026)

Herbal sleep blend

What it is: A blend of calming herbs: valerian, hops, passionflower, skullcap and poppy.

What the research says: Evidence for valerian is inconsistent, and sleep doctors advise against it for chronic insomnia. Small studies suggest passionflower may add sleep time, and hops with valerian may help mild insomnia.

Cautions

• Valerian is generally safe short term; it can cause headache, stomach upset or vivid dreams, and withdrawal if stopped suddenly after long use.
• Passionflower can cause drowsiness or dizziness and shouldn't be used in pregnancy.
• Don't combine with alcohol.

Medicines to check

• Sedatives and sleep medicines: don't combine
• Anesthesia: stop at least 2 weeks before surgery (passionflower)
• Hormone-sensitive cancer: check with your doctor (hops)

In Holitro: Herbal Sleep Blend (450 mg per capsule)

Sources: NIH National Center for Complementary and Integrative Health: Valerian: Usefulness and Safety (updated May 2025); NIH National Center for Complementary and Integrative Health: Passionflower: Usefulness and Safety (updated April 2025); Memorial Sloan Kettering Cancer Center, About Herbs: Hops (updated February 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.