Can I take Ashwagandha with Melatonin SR?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Ashwagandha
+
Melatonin SR

Short answer

We found no documented interaction between Ashwagandha and Melatonin in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Ashwagandha

What it is: A plant root used in traditional Ayurvedic and Unani medicine, often called an adaptogen.

What the research says: Several small trials of 6 to 8 weeks found people felt less stress and anxiety, with doses around 500 to 600 mg a day working better than lower ones. A few small studies suggest a modest sleep benefit. It has not been studied thoroughly.

Cautions

  • Well tolerated for up to about 3 months; long-term safety isn't known.
  • Mild side effects can include upset stomach, loose stools, nausea and drowsiness.
  • It has been linked to liver injury in some people.
  • Not for people who are pregnant or breastfeeding, or who have prostate cancer.

Medicines to check

  • Thyroid medicine (ashwagandha may affect how the thyroid works)
  • Diabetes and blood-pressure medicines
  • Sedatives
  • Medicines that suppress the immune system

In Holitro: Ashwagandha (500 mg per capsule)

Source: NIH Office of Dietary Supplements: Ashwagandha: Fact Sheet for Consumers (updated December 2023)

Melatonin (slow release)

What it is: A slow-release form of melatonin, the hormone the brain makes in the dark to set your sleep-wake clock.

What the research says: Melatonin may help with jet lag and some circadian sleep problems. Sleep-medicine guidelines say there isn't enough evidence to recommend it for chronic insomnia.

Cautions

  • Short-term use seems safe for most people; long-term safety isn't known.
  • Older adults may feel drowsy the next day.

Medicines to check

  • Blood thinners and epilepsy: use only under medical supervision

Source: NIH National Center for Complementary and Integrative Health: Melatonin: What You Need To Know (updated May 2024)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

Stop Guessing Your Dosages.

Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Ashwagandha is already lab-dosed in our Mood Support Pack, and Melatonin SR is in our Sleep Pack — either way, that’s one less bottle to manage.

Shop Mood Support Pack