Short answer

We found no documented interaction between Chromium and Herbal sleep blend in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Chromium

What it is: A mineral found in many foods that may help the body use carbohydrates, fats and protein.

What the research says: Studies on blood sugar are mixed. The American Diabetes Association doesn't recommend it because it has no clear benefit.

Cautions

• No harm has been shown, but research is limited. People with kidney or liver disease should be careful with high amounts.

Medicines to check

• Insulin, metformin and other diabetes medicines: chromium may push blood sugar too low
• Levothyroxine (thyroid medicine): chromium may reduce how much is absorbed

In Holitro: Chromium (1000 mcg per capsule)

Source: NIH Office of Dietary Supplements: Chromium: Fact Sheet for Consumers (updated March 2021)

Herbal sleep blend

What it is: A blend of calming herbs: valerian, hops, passionflower, skullcap and poppy.

What the research says: Evidence for valerian is inconsistent, and sleep doctors advise against it for chronic insomnia. Small studies suggest passionflower may add sleep time, and hops with valerian may help mild insomnia.

Cautions

• Valerian is generally safe short term; it can cause headache, stomach upset or vivid dreams, and withdrawal if stopped suddenly after long use.
• Passionflower can cause drowsiness or dizziness and shouldn't be used in pregnancy.
• Don't combine with alcohol.

Medicines to check

• Sedatives and sleep medicines: don't combine
• Anesthesia: stop at least 2 weeks before surgery (passionflower)
• Hormone-sensitive cancer: check with your doctor (hops)

In Holitro: Herbal Sleep Blend (450 mg per capsule)

Sources: NIH National Center for Complementary and Integrative Health: Valerian: Usefulness and Safety (updated May 2025); NIH National Center for Complementary and Integrative Health: Passionflower: Usefulness and Safety (updated April 2025); Memorial Sloan Kettering Cancer Center, About Herbs: Hops (updated February 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.