Can I take Citrulline with Herbal Sleep Blend?

Understanding the interactions, benefits, and safety of combining these two powerful supplements.

Citrulline
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Herbal Sleep Blend

Short answer

We found no documented interaction between Citrulline and Herbal sleep blend in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Citrulline

What it is: An amino acid the body makes. The kidneys turn most of it into arginine, and then nitric oxide.

What the research says: Research on it as a performance supplement is limited and mixed.

Cautions

  • There isn't enough research to know whether it's safe; some people report stomach discomfort.

In Holitro: Citrulline (500 mg per capsule)

Source: NIH Office of Dietary Supplements: Dietary Supplements for Exercise and Athletic Performance (updated March 2021)

Herbal sleep blend

What it is: A blend of calming herbs: valerian, hops, passionflower, skullcap and poppy.

What the research says: Evidence for valerian is inconsistent, and sleep doctors advise against it for chronic insomnia. Small studies suggest passionflower may add sleep time, and hops with valerian may help mild insomnia.

Cautions

  • Valerian is generally safe short term; it can cause headache, stomach upset or vivid dreams, and withdrawal if stopped suddenly after long use.
  • Passionflower can cause drowsiness or dizziness and shouldn't be used in pregnancy.
  • Don't combine with alcohol.

Medicines to check

  • Sedatives and sleep medicines: don't combine
  • Anesthesia: stop at least 2 weeks before surgery (passionflower)
  • Hormone-sensitive cancer: check with your doctor (hops)

In Holitro: Herbal Sleep Blend (450 mg per capsule)

Sources: NIH National Center for Complementary and Integrative Health: Valerian: Usefulness and Safety (updated May 2025); NIH National Center for Complementary and Integrative Health: Passionflower: Usefulness and Safety (updated April 2025); Memorial Sloan Kettering Cancer Center, About Herbs: Hops (updated February 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.

Stop Guessing Your Dosages.

Balancing dosages across multiple different bottles is risky, inefficient, and expensive. Herbal Sleep Blend is already lab-dosed and delivered daily in our Sleep Pack — one less bottle to manage.

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