Short answer

We found no documented interaction between Vitamin D3 with A, E and K2 and Herbal sleep blend in the sources below. That isn't proof the combination is right for you: check each one's cautions, and ask your pharmacist if you take medication.

Vitamin D3 with A, E and K2

What it is: A combination of vitamin D3 with vitamins A, E and K2. Vitamin D helps the body absorb calcium and supports muscles, nerves and the immune system.

What the research says: Getting enough vitamin D and calcium helps protect against osteoporosis.

Cautions

• Adults shouldn't exceed 4,000 IU (100 mcg) of vitamin D a day from all sources unless a clinician advises more. Too much can cause nausea, weakness, confusion and kidney stones.
• Too much preformed vitamin A can cause headaches and blurred vision, and birth defects in pregnancy.
• High-dose vitamin E supplements may raise bleeding risk.

Medicines to check

• Warfarin: vitamin K and vitamin E both matter, and vitamin K intake should stay steady
• Statins, steroids, orlistat and thiazide diuretics (vitamin D notes)
• Vitamin A-based medicines such as acitretin

In Holitro: D Complex (5,000 IU per capsule)

Sources: NIH Office of Dietary Supplements: Vitamin D: Fact Sheet for Consumers (updated November 2022); NIH Office of Dietary Supplements: Vitamin A: Fact Sheet for Consumers (updated March 2025); NIH Office of Dietary Supplements: Vitamin E: Fact Sheet for Consumers (updated March 2021); NIH Office of Dietary Supplements: Vitamin K: Fact Sheet for Consumers (updated March 2021)

Herbal sleep blend

What it is: A blend of calming herbs: valerian, hops, passionflower, skullcap and poppy.

What the research says: Evidence for valerian is inconsistent, and sleep doctors advise against it for chronic insomnia. Small studies suggest passionflower may add sleep time, and hops with valerian may help mild insomnia.

Cautions

• Valerian is generally safe short term; it can cause headache, stomach upset or vivid dreams, and withdrawal if stopped suddenly after long use.
• Passionflower can cause drowsiness or dizziness and shouldn't be used in pregnancy.
• Don't combine with alcohol.

Medicines to check

• Sedatives and sleep medicines: don't combine
• Anesthesia: stop at least 2 weeks before surgery (passionflower)
• Hormone-sensitive cancer: check with your doctor (hops)

In Holitro: Herbal Sleep Blend (450 mg per capsule)

Sources: NIH National Center for Complementary and Integrative Health: Valerian: Usefulness and Safety (updated May 2025); NIH National Center for Complementary and Integrative Health: Passionflower: Usefulness and Safety (updated April 2025); Memorial Sloan Kettering Cancer Center, About Herbs: Hops (updated February 2021)

Check with your doctor or pharmacist, especially if you take medication.

Check your stack — free

Educational information only, not medical advice. This reflects general ingredient overlap, not a personalized safety review. Always check with your doctor or pharmacist before combining supplements, especially if you take medication, are pregnant or nursing, or manage a health condition. These statements have not been evaluated by the FDA.